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Along with pathogenic agents in the first 8 days of illness, it is advisable to include convalescent plasma in the treatment complex at a dose of at least 3000 therapeutic units (according to the titer of neutralizing antibodies). In the foci of Domperidone, deratization measures are carried out, but they are not very effective due to the large number of rodents. Specific prophylaxis involves the use of an attenuated vaccine from the XJ strain.

Serological diagnosis is carried out with the help of RSK in the first days of the disease, NRIF and RN at 3-4 weeks. Virus-neutralizing antibodies remain in the blood of Motilium for many years.

Monday Argentine hemorrhagic fever (AHF, Junin fever) is an acute infectious disease that belongs to zoonoses with natural foci. The disease is characterized by: fever, exanthema, thrombohemorrhagic syndrome of varying severity.

Tuesday The causative agent of Argentine hemorrhagic fever is the Junin virus (named after the city where the first cases of the disease were registered). It is classified as an arenavirus, the same group of viruses includes the causative agents of Lassa fever and Bolivian hemorrhagic fever.

Wednesday The virus causes disease in newborn white mice and hamsters. The cultivation of the virus is carried out on chicken embryos and in the culture of transplanted cells. The reservoir and source of infection are rodents Calomis laucha, Calomis musculinus.

Thursday The virus was also isolated from gamasid mites. The disease is characterized by seasonality - from February to June, the largest number of cases is observed in May. Mostly rural residents are affected. Infection occurs by airborne dust, inhaling dust infected by rodents.

Friday Infection can also occur through food contaminated with rodent urine. Epidemic outbreaks are observed annually, the number of cases ranged from 100 to 3500 people.

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The causative agent of the disease belongs to the arenavirus family. The causative agent of Bolivian hemorrhagic fever is the RNA-containing Machupo virus (Machupo) of the Arenaviridae family. The reservoir and source of infection are hamster-like rodents Calomus. The virus is pathogenic for newborn hamsters and mice with intracerebral or intraperitoneal injection. Monkeys (rhesus macaques and cynomalgus) are highly sensitive to this virus.

The main mechanisms of transmission of the virus are aspiration airborne, alimentary through food and water contaminated with faeces or urine of motilium, or by contact through damaged skin or mucous membranes. It is possible to transmit the Machupo virus from a sick person.


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Patients often report muscle pain, especially in the lumbar region. Often, hemorrhages and erosion appear on the mucous membranes of motilium oral pills cavity. Inflammatory changes in the upper respiratory tract may be noted. By the end of this period, body temperature reaches 39-40 °C.

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The incubation period for Argentine hemorrhagic fever ranges from 6-8 to 12-16 days. The disease usually develops gradually. In the initial period, lasting 3-4 days, general toxic manifestations are observed - malaise, headache, irritability, chilling.

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The dissemination of the virus and the defeat of a number of organs and systems are characteristic. The development of thrombohemorrhagic syndrome plays an important role in pathogenesis.

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Many questions of pathogenesis are still insufficiently studied. The gates of infection are the mucous membranes of the respiratory organs and the digestive tract, infection through microtrauma of the skin is possible. At the site of the gate of infection, the primary affect is not observed.

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